I found the angle of the seat (to accommodate the charger beneath) to be a big problem; it slides you down off the area that would normally accommodate your sit bones (ischial tuberosities) and the drop-off to the sides of the forward portion of the seat insures that the body's pressure is sitting on your perineum, just like a BAD bicycle seat.
Along with the taut suspension, thin seat padding, and my skinny butt... not a comfortable experience.
The AirHawk can help, but, for everyday riding, I don't like its lack of stable feeling. Works pretty well for long trips, however. Many people love them in all conditions.
I had the rear shock re-valved and eventually got a custom seat made which is worlds better than OEM. Bill Mayer was able to build up the front portion of the seat, mitigating the angle-slide effect, and widen the rear and install his "tractor seat" butt-molded insert in the saddle. I rode 500 miles to get it - in agony; and 500 miles to come home in relative bliss.
Another trick is to put weight on your feet a lot and grip the tank with your knees at the same time. This builds good leg muscles, anchors the bike's handling, and relieves the butt's burden. Not a "solution" but it helps.